Main Street Bed & Breakfast - Hannibal

Historic Downtown Hannibal Bed & Breakfast in a Former Bank Building

Amenities & Services

Main Street B&B offers free private parking on-site, a rare convenience in this downtown district. The property has a hot tub and spa bath available in select rooms, along with bicycle rental for exploring the area. Guests receive homemade breakfast treats delivered directly to their room each morning, alongside a stocked refrigerator with yogurt and fruit.

Rooms & Accommodations

The rooms at Main Street Bed & Breakfast are located on the second floor of an 1875 building, accessible via a winding staircase. Each room is themed with period-appropriate decor and features a private bathroom, air conditioning, and soundproofing. The Deluxe Queen Suite includes a jetted tub for two and views of the Mississippi River from select rooms.

Location & Surroundings

This Main Street Inn B&B sits in the center of historic Hannibal, within walking distance of the Mark Twain Boyhood Home and Museum. The Mississippi River is one block away, offering riverboat cruises and waterfront walks. Downtown restaurants, shops, and the Bluff City Theater are all reachable on foot.

Activities & Entertainment

Main Street B&B Hannibal MO provides bike rental and walking tours for guests to explore the town and riverfront. Evening entertainment options include live music at nearby venues and pub crawls organized by local guides. Tour or class about local culture is available through the hotel's connections with historians.

Dining & Breakfast

Each morning, guests at Main Street Bed & Breakfast Hannibal find a basket with homemade quick bread (such as pumpkin or chocolate chip), granola bars, and snacks. The in-room refrigerator is stocked with bottled water, yogurt, and fruit cups for a self-serve continental breakfast. The property also offers special diet menus upon request and has BBQ facilities on-site.

• Location: Heart of historic downtown Hannibal, one block from Mississippi River
• Rooms: Themed Deluxe Queen Suites with jetted tubs and river views
• Dining: Homemade bread and continental breakfast delivered to room
• Amenities: Free private parking, bicycle rental, hot tub, BBQ facilities
• Activities: Walking tours, bike tours, pub crawls, local culture classes